Abstract
More than a quater century ago, investigation of an artificial membrane had a significant influence on the research of biological membrane theoretically and biologically. Nernst-Planck equation, Donnan equilibrium, Goldman-Hodgkin-Katz equation, phenomenological equation based on nonequilibrium thermodynamics had played an important role for the explanation of transport phenomena through biological membrane and the development of ion-exchange membranes. Recently, understanding of structure on membrane protein has been more and more facilitated.Therefore it will be possible to investigate the transport phenomena of ions through channel protein in the field of molecular theory and explain the mechanism of gating precisely. In this review the way how to approach the problems in channel protein and gate is discussed from the viewpoint of artificial membrane research.
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