Лазерное облучение в профилактике начальных проявлений сердечной недостаточности у больных ишемической болезнью сердца

Abstract

Objective. To study cardiodynamic changes in patients with IHD under laser irradiation (LI) as compared to highly effective neurohormonal modulator Carvedilol, a beta-blocker. Material and methods. 115 men (males) under 60 years with IHD and tension angina pectoris of the functional class II-III were taken into the trial. All patients were divided into two groups. In Carvedilol group ( 65 patients) 53 patients received 50 mg of Carvedilol for 7 days and 12 patients received Carvedilol placebo. In the laser therapy group ( 50 patients) 39 were treated with infrared LI therapy for 10 days and 11 patients had sham LI. The bicycle ergometer test and ultrasound heart examination were performed in all patients receiving Carvedilol and LI at the beginning of treatment and after it. Results. A 10-day course of laser therapy increased the tolerance to physical loading comparable to Carvedilol therapy (+35.0% and +34.1%). Besides, a statistically important improvement of cardiodynamics was noticed too. It was characterized with the decrease of peripheral vessel resistance by 19%, with the increase of left ventricular ejection fraction by 9.1% as well as by the improvement of cardiac diastolic function (increase of early transmitral blood flow ratio to the late transmitral blood flow ratio - E/A by 21.8%). Similar results were seen in patients treated with Carvedilol (-9.2%, +11.4%, +20.4%). Conclusion. A revealed similarity in positive cardiodynamic changes with similar improvement of functional class in patients with IHD under laser therapy and under beta blockers (Carvedilol) motivates the authors to recommend LI therapy in the complex treatment of heart failure at early stages.