Abstract
The purpose of this study was to analyzed whether the genetic polymorphisms in the candidate genes including COL1A1, COL3A1 and MMP3 genes are significantly associated with the vulnerability to anterior cruciate ligament(ACL) rupture with surgery experience. A total of 153 subjects were recruited in this study, and they were divided into both ACL rupture group(n=80) and control group(n=73) by clinical status. In the case of ACL rupture patients, they all experienced the surgery. Automated DNA isolation kit isolated total genomic DNA, and the genetic analyses of these candidate genes were performed by using SNaPshot method. Among three candidate genes analyzed, the rs#1800012 polymorphism in COL1A1 gene indicated the monomorphic pattern in this study. Also, with respect to the rs#1800255 polymorphisms in COL3A1 gene, there were no significant differences in the genotype and allele frequencies of this genetic polymorphism between both groups, respectively. In the case of the rs#679620 polymorphism in MMP3 gene, this genetic polymorphism was significantly associated with the susceptibility to ACL rupture in this study(p.05), and especially, the GG genotype and G allele of this genetic polymorphism indicated the significant association with ACL rupture risk. Further studies will be needed to define the precise role of the rs#679620 polymorphism in MMP3 gene on the occurrence of ACL rupture.
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