Abstract
One of the new focuses of the biological science was genomic science during the 20th century. The new frontier for the 21st century is protein science. Fundamental thermodynamic and kinetic theories, especially volume changes and activation volumes, for the pressure denaturation of proteins are described. The recent studies of molecular structure of proteins utilizing high-pressure spectroscopes (FTIR, NMR, SAXS) and the MD computer simulation are reviewed.
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