Abstract
A case of glioblastoma was found in a 6-month-old Holstein cow. The animal showed ataxia and had a neoplastic nodule occupying a part of the lower cerebellum and the cerebellar peduncle. The neoplastic tissue was composed of pleomorphic cells frequently displaying mitosis and was accompanied by necrosis and haemorrhage. There were many blood vessels and a considerable amount of collagen fibres in part of the neoplastic tissue. Some neoplastic cells were stained positively with anti-glial fibrillary acidic protein (GFAP) serum, and a large number of cells revealed S-100α or S-100β positivity. Neuron-specific enolase (NSE)-positive cells were rarely seen. The histological and immunohistochemical features in the present case are discussed in comparison to those in other primary neoplasms of the nervous system.
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