Year-end Sale % OFF 
Abstract
A method was developed for quantification of six organophoshorus pesticides ( OPP ): chlorophos, dimethoate, chloropyrifos, fosalon, diazinon, and methyl parathion. The method allows the target compounds to be determined at a level of 1 ng/ml (1 ppb) in blood and urine samples by gas chromatography with tandem mass-selective detection. Sample preparation procedure includes salting and liquid-liquid extraction with acetonitrile. Method has passed methrological certification (certificate № 222.0320/01.00258/2013), and can be used for monitoring of employees engaged in the production and use of pesticides, as well as those with low levels of cholinesterase activity, or with the corresponding clinical symptoms. The detection limit makes it possible to reveal the intake of OPPs over a period of up to 6 days post exposure at doses equvalent to 1/10−1/50 LD 50 . The method was tested in a toxicological experiment on male rabbits after oral administration of mixture of six OPP’s. Doses of OPP’s was equivalent to 1/10 LD50 and 1/50 LD50. The main toxicokinetic parameters of dimethoate, chloropyrifos, fosalon, diazinon, and methyl parathion was evaluated. Key words : organophosphorus pesticides, GC-MS, blood, urine. (Russian) DOI: http://dx.doi.org/10.15826/analitika.2014.18.3.004 A.I. Ukolov, P.N. Sorokoumov, E.S. Ukolova, E.I. Savel’eva, and A.S. Radilov Research Institute of Hygiene, Occupational Pathology and Human Ecology Federal State Unitary Enterprise, Federal Medical Biological Agency of Russia , Kapitolovo Station, g/p Kuz’molovsky, Vsevolozhsky District, Leningrad Region, Russian Federation
Published Version (
Free)
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
