Abstract
A 68-year-old man presented with more than 30 brownish papules up to 2 mm in diameter on the penis. Histologically, there were marked hyperkeratosis and acanthosis with prominent granular degeneration. The eruption was diagnosed as localized multiple epidermolytic acanthoma. We immunohistochemically studied the expression of various antigens in the specimen along with epidermal nevus with granular degeneration, exhibiting bullous congenital icthyosiform erythroderma, and normal skin. Cytokeratin (CK) 10 and CK1 were not homogeneously distributed in the disordered granular layer, in comparison with the normal granular layer. CK17 was partly stained in the granular layer of the localized multiple epidermolytic acanthoma, but not in the other two diseases, carcinoembryonic antigen was expressed not only in the disordered granular layer but also in the adjacent normal-appearing granular layer. Therefore, we considered that the epidermis surrounding the papules had the same abnormality as the lesional skin.
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