Abstract
It is well recognized the PGC-1 alpha is a key regulator of mitochondrial biogenesis. Mechanical and metabolic perturbations in a skeletal muscle during and after aerobic exercise lead to increase PGC-1alpha expression. In addition to that an increase of PGC-1alpha expression after exercise depends on relative workload intensity and does not depend on fitness level. The aim of the study was to compare the expression of regulators of mitochondrial biogenesis PGC-1alpha, TFAM and TFB2M and of proteolysis-related genes FOXO1 and Atrogin-1 in skeletal muscle untrained and trained men after aerobic exercise with the same relative workload. The study showed that after exercise the PGC-1alpha expression did not differ between groups but TFAM and TFB2M expression was higher in untrained muscle than trained. On the contrary proteolysis-related genes FOXO1 and Atrogin-1 expression increased only in the muscle of trained men.
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