СТРУКТУРНО-ФУНКЦИОНАЛЬНОЕ СОСТОЯНИЕ БЕЛКОВ В ЭРИТРОЦИТАРНЫХ МЕМБРАНАХ ПАЦИЕНТОВ С АРТЕРИАЛЬНОЙ ГИПЕРТЕНЗИЕЙ

Abstract

Objective. To study the structural and functional state of proteins in erythrocyte membranes of AH patients with asymptomatic brain lesions (ABL) and AH patients without brain lesions who suffered from cerebrovascular accident (CVA). Methods. The study included 47 patients diagnosed with AH. The study groups were formed based on the detected neuroimaging changes in the brain and analysis of the structural and functional state of proteins in the membranes of erythrocytes in patients with AH. The following groups were identified: 1-рatients with AH without BL 2-patients with AH and ABL 3-patients with previous cerebrovascular accident Results. A comparative analysis of abnormalities of structural and functional state of proteins in erythrocyte membranes in patients with AH without brain lesions, in patients with AH with asymptomatic brain lesions visualized by MRI, and patients who suffered from cerebrovascular accident showed the following: 1. In patients with AH with asymptomatic brain lesions, and in those suffered from cerebrovascular accident, the value of the maximum reaction rate (Vmax) of AChE in erythrocyte membranes was significantly reduced in comparison with the values of this parameter in patients with AH without brain lesions (Figure 1). 2. The value of Michaelis constant (MC) for AChE in isolated erythrocyte membranes of patients with AH without brain lesions and with asymptomatic brain lesions is increased compared with the group of patients with a history of cerebrovascular accident (Figure 2). Conclusion. In patients with hypertension, the structural and functional state of proteins in erythrocyte membranes is disturbed, depending on the severity of the damage to the brain.