들깻잎과 참깻잎 추출물의 항산화 활성 및 대장암세포 증식 억제 활성 비교분석

Abstract

Abstract This study was to compare the antioxidant and anti-proliferative activities of perilla (Perilla frutescens Britton) and sesame (Seasamum indicum L.) leaf extracts. The total polyphenol levels of sesame leaf (634.7 ± 1.2 mg gallic acid equivalent/100 g dried leaf) were higher than those of perilla leaf (408.7 ± 4.6 mg gallic acid equivalent/100 g dried leaf; p<0.001). The total flavonoid levels of sesame leaf (166.7 ± 17.3 mg quercetin equivalent/100 g dried leaf) were also higher than those of perilla leaf (108.2 ± 3.7 mg quercetin equivalent/100 g dried leaf; p<0.05). ABTS radical- and DPPH radical-scavenging activities of sesame leaf extracts (78.9% and 18.2%, respectively) were higher than those of perilla leaf extracts (46.0% and 9.0%, respectively; p<0.01). Both perilla and sesame leaf extracts significantly inhibited the growth of HCT116 human colon cancer cells. However, the inhibitory activities of sesame leaf extracts were more pronounced than those of perilla leaf extracts (p<0.001). These results indicate that sesame leaf extracts have higher antioxidant and anti-proliferative activities than perilla leaf extracts. More studies are needed in order to enhance the sensory value of sesame leaf and to develop sesame leaf as health/functional food ingredients.Key words : Sesame leaf, perilla leaf, antioxidant activity, anti-proliferative activity, HCT116 colon cancer cell