膀胱内壓測定知見補遺 (藥理學的研究)

Abstract

The author has investigated, in some 200 cases of adults about 600 times, about the influences of autonomic nervous drugs, ergot, morphine and various hormones upon normal or abnormal bladders with using cystometrograms.Method of experiment: The therapeutic dosis of these drugs are injected subcutaneously or sometimes intramuscularly once or more times, and the results are measured comparing with the results before injection. For the purpose of measuring the intravesical pressure, a catheter inserted in bladder, a syringe and a mercury manometer are connected with a three-way valve by a rubber-tube. Then sterilized water is introduced intermittently. In interpreting the cystometrogram, following 4 points were taken into consideration:(1) the minimum desire to void, (2) the maximum desire to void, (3) the maximum voluntary pressure, (4) the character of tonus curve.I. Influence of Autonomic Nervous Drugs, Ergot and Morphine1) Adrenalin, generally speaking, acts upon the bladder hypotonic, however there is no marked difference between normal and abnormal bladder. The action of atropin is similar to that of adrenalin, but its action is much stronger than adrenalin, particularly in the abnormal hypertonic bladder. This is the reason why atropin is used for the treatment of enuresis nocturna.2) Acetylcholin, arecorin and vagostigmin all act upon bladder hypertonic, particulary in the abnormal hypotonic bladder. Among these drugs acetylcholin acts most remarkably.3) Benzylimidazolin acts occasionaly hypertonic.4) Secalamin (preparation of ergot) and morphine act hypertonic, particularly in the abnormal hypotonic bladders. The change of minimum or maximum desire to void with that of the maximum voluntary pressure and tonus curve also shows no coincidence, in using both drugs.