Парвальбумин-содержащие энтеральные метасимпатические нейроны в постнатальном онтогенезе

Abstract

Calcium-binding protein parvalbumin (PB) is selectively expressed in various populations of neurons in the central and peripheral nervous system. The localization and percentage of PB-immunoreactive (IR) neurons was determined in the neurons of metasympathetic enteric ganglia of the small and large intestine in rats of different ages (1, 10, 20, 30, 60 days and 2 years). In the myenteric plexus (MP) PB-IR neurons are detected in ontogenesis from birth to old age, while their percentage in the MP of small intestine increases from 10 to 20 days of life, in the MP of the colon - in the first 10 days of life. In the submucosal plexus (SP) of the small and large intestine in newborn pups, PB is absent and it is determined from 10 days of life. The percentage of PB-IR neurons in the SP increases between 10 and 20 days of life. With aging, the proportion of PB-IR neurons in the MP and SP does not significantly change. Thus, in the early postnatal ontogenesis, there is an increase in the proportion of PB-IR neurons in the gut methasympathetic intramural ganglia. This increase is likely due to the buffer role of PB in relation to Ca2 + ions.