Abstract
This study was carried out to determine the different densities in laryngeal intraepithelium of substance P (SP) and calcitonin gene-related peptide (CGRP) immunoreactive (IR) nerve fibers in the dog, rat, guinea pig and cat. In the supraglottic and subglottic regions, the densities of SP and CGRP IR nerve fibers occured in decreasing order as follows: dog, rat, guinea pig and cat. Only a few fibers were found in the vocal folds of all species. We observed a greater density of CGRP IR nerve fibers than SP in all the animals studied. It was suggested that the difference in the distribution of SP and CGRP IR nerve fibers is related to differences in the sensory and reflex system of the larynx.
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