포도씨 추출물 섭취가 경계성 고혈압자의 안정 시와 운동 중 심혈관반응과 혈관내피세포기능에 미치는 영향

Abstract

The aim of this study was to investigate the effects of a 2-week ingestion of grape seed extract(300 mg/day) on cardiovascular response and vascular endothelial cell function at rest and during handgrip exercise in prehypertensive individuals. Nine prehypertensive men, aged 24.6±3.1 yrs, repeatedly participated in both grape seed extract trial and placebo trial in a randomized, double-blind, crossover manner. While the subjects ingested grape seed extract or placebo in a 2-week trial, their cardiovascular response, blood vessel diameter, blood flow volume, and vascular endothelial cell function at rest and during handgrip exercise were measured. Each variable was compared between two trials as well as between two tests simultaneously using a repeated two-way ANOVA. Main result of the present study were as follows: 1) Systolic blood pressure decreased significantly at rest after the 2-week ingestion of grape seed extract. 2) Systolic blood pressure and mean blood pressure decreased significantly during handgrip exercise after the 2-week ingestion of grape seed extract. 3) Flow-mediated dilation volume and % flow-mediated dilation increased significantly after the 2-week ingestion of grape seed extract. It was concluded that 2 weeks of ingestion of grape seed extract would have an positive effect on cardiovascular response and vascular endothelial cell function at rest and during handgrip exercise in prehypertensive men. Future research investigating the effects of various period and amount of ingestion of grape seed extract during aerobic exercise including large muscle group would be warranted.