諸種利尿劑, 特に脂肪酸塩類, 尿素及びプリン誘導體の経口的適用による作用比較

Abstract

Experiments were performed under the normal physiological conditions on a caged rat with free access to water. The diuretic action and the amount of water drunk were compared at regular. intervals after the oral administration of diuretics of various kinds, such as coffein, theocin, urea, potassium chloride, potassium and sodium salts of acetic, succinic and suberic acid. All the experiments were planned statistically and carried out with the method, of uniformity test, and of cross test as, well : as with. Latin square method. First, in the method of uniformity test, 10 mg, 30 mg and 60, mg of. caffein, and, theocin were respectively administered per kg body. weight.but neither diuretic action nor an increase in the amount of water drunk were recognized. Then, 1, 000 mg of urea and 300 mg per kg of potassium chloride were administered. In the case of urea, a remarkable diuretic effect and an increase in the amount of water drunk were recognized. In the case of potassium chloride, temporary diuretic effect was found immediately after its administration and then, the amount of urine gradually decreased and in 5 or 6 days became smaller than before the administration. In the case where 23.5 mg of potassium acetate, 23 mg of potassium succinate and 30 mg of potassium suberate kneaded with a constant amount of wheat flour respectively (each dose is equimolar to the other) were administered, neither diuretic effect nor increase in amount of water drunk was observed, whereas with doses ten times as much as the doses of these compounds respectively, all caused distinct diuretic and increase in the amount of water drunk, although the effect of potassium succinate is less remarkable than those of the other two. Next, the experiments were made by the method of cross test. In this case, too, almost the same distinct diuretic effect and increase in the am ount of water were observed, by using potassium. acetate and potassium usberate. Furthermore, the results obtained by the Latin-square method with those compounds were the same as those of the above-mentioned two methods. When experiments were carried, out in the same, manner as before with their sodium salts instead of potassium salts, suberate showed a slight diuretic effect, while no diuretic action was. recognized in the cases of both acetate and succinate.