Abstract

The research aim is to identify the correlation between circadian rhythm in terms of changes in the chronotype of human working capacity and severity of psoriasis progression, obesity, and the disease impact on the quality of patients' life. Materials and Methods. The research focuses on the determination of the PASI, BMI, DIAG indexes and a patient's chronotype of working capacity. Results and Discussion. The results of the correlation analysis showed a very high negative correlation between chronotype of patients' working capacity and BMI. They also demonstrated a high negative correlation between PASI and DIAG indicators and chronotype of patients' working capacity. Conclusions. The circadian rhythm changes to the evening chronotype of human working capacity contribute to psoriasis worsening, weight gain, and negative impact of the disease on the quality of patients' life.

Highlights

  • Ðàðõ3÷íó ñòðóêòóðó, ÿêà ñèíõðîí3çóo âñ3 ô3ç3îëî3÷í3 ïðîöåñè â îðàí3çì3 ì3æ ñîáîþ 3 ç ðèòìàìè íàâêîëèøíüîãî ñåðåäîâèùà [8, 9]

  • The research aim is to identify the correlation between circadian rhythm in terms of changes in the chronotype of human working capacity and severity of psoriasis progression, obesity, and the disease impact on the quality of patients' life

  • The research focuses on the determination of the PASI, BMI, DIAG indexes and a patient's chronotype of working capacity

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Summary

Introduction

Ðàðõ3÷íó ñòðóêòóðó, ÿêà ñèíõðîí3çóo âñ3 ô3ç3îëî3÷í3 ïðîöåñè â îðàí3çì3 ì3æ ñîáîþ 3 ç ðèòìàìè íàâêîëèøíüîãî ñåðåäîâèùà [8, 9]. Âèÿâëåííÿ êîðåëÿö3éíî¿ çàëåæíîñò3 ì3æ öèðêàäíèì ðèòìîì çà ïîêàçíèêàìè çì3í õðîíîòèïó ïðàöåçäàòíîñò3 ëþäèíè òà ïîêàçíèêàìè òÿæêîñò3 ïåðåá3ãó ïñîð3àòè÷íî¿ õâîðîáè, ñòóïåíåì îæèð3ííÿ, òà ñòóïåíåì íåàòèâíîãî âïëèâó çàõâîðþâàííÿ íà ÿê3ñòü æèòòÿ ïàö3oíò3â. Çì3íè öèðêàäíîãî ðèòìó íà âå÷3ðí3é òèï õðîíîòèïó ïðàöåçäàòíîñò3 ëþäèíè ñïðèÿo ïîã3ðøåííþ ïåðåá3ãó ïñîð3àòè÷íî¿ õâîðîáè, çá3ëüøåííþ ìàñè ò3ëà òà òÿæêîñò3 íåàòèâíîãî âïëèâó çàõâîðþâàííÿ íà ÿê3ñòü æèòòÿ ïàö3oíò3â.

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