Abstract
We carried out immunohistochemical investigations on the relationship between the expression of E-cadherin and the clinical stage and mode of invasion of human primary oral cancers (squamous cell carcinomas).We found that cancers having a grade 4 mode of invasion displayed a reduced type of E-cadherin expression by the classification of Shiozaki et al.This suggests that decreased expression of E-cadherin is closely related to the high invasiveness of cancer cells.
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