Abstract
Ethanolamine oleate (EO) injection containing a contrast medium has been used as an agent for sclerosing treatment (endoscopic embolization) of esophageal varix.We tested the compatibility of 10% ethanolamine oleate injection [Oldamin for Injection (OD)] with 3 kinds of contrast media [Iopamiron 300 (IP300), Omnipaque 300 (0P300), Isovist 240 (IV240)] and water for injection.The sterilized samples were stored for three months at 6° and 25°, and the unsterilized samples for a week at 25° and 40°.The changes in appearance, pH, viscosity, osmotic pressure, and contents of the contrast medium, oleic acid and benzyl alcohol, and the concentration of iodide (contaminant) were examined at intervals.In all samples, no significant changes were observed in each test item except the concentration of iodide and appearance. After sterilization, OD-0P300 showed the highest concentration of iodide (206μg/ml, while ODIP300 and OD-IV240 showed 36μg/ml and 105μg/ml, respectively) and yellow coloration.The concentration of iodide in OD-OP300 and OD-IV240 increased during the storage at 25° and 40°, while the concentration in OD-1P300 did not change for the storage.These results suggest that Iopamiron 300 is the most appropriate contrast medium which is combined with 01-damin for Injection among the 3 kinds of contrast media.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
