Особливості імунних порушень у дівчат із рецидивами хронічних неспецифічних запальних захворювань статевих органів

Abstract

Nonspecific inflammatory diseases of the female genital organs (NIDFGO) affect women throughout their lives and are an important medical and social problem associated with a decrease in a woman's reproductive potential. Purpose - to study the immune status of girls with HCV in comparison with changes in adult women in order to improve algorithms for the diagnosis and treatment of inflammatory vaginal lesions depending on age. Materials and methods. In a prospective, single-center controlled and non-randomized study, 69 girls were involved: 55 patients with NIDFGO, who had a different frequency (from 1 to 4 or more) of disease recurrence during 1 year of observation, and 14 healthy girls of the control group. All study participants underwent a standard gynecological examination and laboratory screening. The research was carried out in accordance with the principles of the Helsinki Declaration. The study protocol was approved by the Local Ethics Committee of the Bogomolets National Medical University. The informed consent of the children’s parents was obtained for the conducting the studies. Statistical analysis was performed using the IBM SPSS Statistics 23 package and the MedStat program. Results in groups were compared using Kruskal-Wallis, Dunn, or Mann-Whitney tests with Bonferroni correction. Results. Selective deficiencies of IgE and NKT-cells are the main immune disorders in patients with , NIDFGO of both age groups. Deficiencies of IgA, C3 component of the complement system and qualitative phagocytic disorders are registered only in girls, while in adult women, deficiency of C4 component of complement, CD8+ cytotoxic T-lymphocytes and NK cells predominate. Conclusions. The opposite direction of changes in the content of the IgE molecule and the number of NKT cells in the blood in patients with NIDFGO in different age groups, with the preservation of the ratio of results in subgroups with different frequency of relapses, indicates the need for a differentiated approach to the diagnosis, treatment and prevention of immune disorders in people with recurrent NIDFGO in different age groups. No conflict of interests was declared by the authors.