Abstract
Irritable bowel syndrome (IBS) and functional dyspepsia (FD) overlap is an adverse clinical case, which is associated with clinical manifestation aggravation of each of the diseases and a significant life quality reduction. Comorbidity occurrence in functional gastrointestinal disorders (FGID) is due to the presence of common risk factors and pathogenetic mechanisms. This review is aimed at systematization of the available data on the FGID etiopathogenesis. The role of genetic factors, nervous control, in particular n. vagus, providing afferent and efferent interaction between intestine and brain, as well as infectious agents that cause the low-grade inflammation preservation in the intestinal mucosa, is considered. The article also shows the role of mast cell mediators that alter gastrointestinal motility and secretion. The role of Helicobacter pylori in the formation of FGID is considered separately. The importance of a detailed diagnosis during the examination of patients with FGID was noted to exclude serious organic pathology with similar symptoms. The main methods of correction in the conditions of FD and IBS comorbidity are indicated. KEYWORDS: overlap syndrome, functional dyspepsia, irritable bowel syndrome, inflammation, comorbidity. FOR CITATION: Livzan M.A., Lisovskiy M.А., Gaus O.V. Irritable bowel syndrome and functional dyspepsia overlap: modern ideas concerning the pathogenesis and drug correction opportunities. Russian Medical Inquiry. 2023;7(7):439–444 (in Russ.). DOI: 10.32364/2587-6821-2023-7-7-6.
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