Новые возможности лечения синдрома «сухого глаза» у пациентов с первичной глаукомой

Abstract

Purpose: To evaluate the efficiency of Oсuhyl C moisturizing ophthalmic solution in patients with dry eye syndrome (DES) and primary glaucoma. Methods: The study included 26 patients (47 eyes) with different stages of primary open-angle glaucoma, mean age 68.62±1.76 years. Duration of instillation of hypotensive eye drops with preservatives ranged from 1 year to 35 years. Intraocular pressure (IOP) was compensated prior to the examination. Subjective DES signs assessment included a three-point scale questionnaire: 0 points — no sign, 1 point — periodic occurrence, 2 points — constant presence. The following functional tests were performed in all the patients: the Norn test for the stability of the precorneal tear film, the Shirmer test for assessing the level of total tear production. Examinations were carried out prior to drug administration and after 4 and 8 weeks of its use (sodium hyaluronate 0.12% 1 drop 3 times a day after 10 min after antihypertensive drugs). Results: All patients noted good tolerability of the drug and no significant side effects. Feeling of a foreign body, dryness and eye redness were significantly decreased after the drug instillations. The initial total tear production on average was 8.94±1.12 mm, after 8 weeks it increased to 11.55±1.01 (p<0.1). The time of the precorneal tear film rupture increased significantly from 8.21±0.31 seconds to 15.06±0.61 (p<0.001). Conclusion : Ocuhyl C has a positive effect on reducing DES symptoms in patients with primary glaucoma and a long-term use of antihypertensive therapy with preservatives, and can be recommended for clinical use.