Abstract
The current study was aimed to reveal the reaction of the insulin production system to alloxan diabetes. In the pancreas that system is comprised by islets (60.93 %), b-cell agglomerates (19.37 %) and singular b-cells in acinar (13.13 %) and ductal (6.56 %) epithelium. Based on the insulin production intensity, islets are classified as high- (type I), medium- (type II), and low- (type III) activity. Alloxan treatment leads to the progressive destruction of insulin-producing cells, with islets being the most susceptible to the b-cell death. The compensatory mechanisms in the islets are implemented through either increased b-cell proliferation combined with their decreased proliferation. Cell hypertrophy and significant increase in the number of cells in ductal epithelium is found in the extra-islet insulin-producing structures.
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