Вагітність і пологи у жінок з недиференційованою дисплазією сполучної тканини: діагностика і профілактика гестаційних ускладнень

Abstract

The objective: depression of frequency of obstetric and perinatal pathology at women with undifferentiated dysplasia of connecting tissue on the basis of improvement and introduction of algorithm of diagnostic and treatment-and-prophylactic actions. Materials and methods. 295 women, from which main group were surveyed: 265 women with an undifferentiated dysplasia of connecting tissue aged from 19 till 45 years (middle age – 29.5±0.5) before pregnancy, in I, II and the III trimesters of pregnancy, in the puerperal period. Control group: 30 healthy women aged from 19 till 40 years (middle age – 27.1±1.8). The complex of the conducted researches included clinical, functional, tool, laboratory, morphological and statistical methods. Results. Use improved by us to algorithm allowed to normalize a functional condition of fetoplacental complex, vegetative nervous system and the psychological status that, in turn, led to depression of frequency of preeclampsia from 44.0% to 32.0%, placental dysfunction from 50.0% to 34.0%, premature births – from 6.0% to 4.0%, an abdominal delivery – from 64.0% to 46.0% and perinatal losses – from 18.0‰ to 10.0‰. Сonclusion. The presented results of researches allow to come to conclusion about positive influence of the algorithm improved by us at pregnant women with an undifferentiated dysplasia of connecting tissue on obstetric and perinatal results of a delivery. The obtained data allow us to recommend advanced algorithm of diagnostic and treatment-and-prophylactic actions for wide use in practical health care. Key words: pregnancy, labors, undifferentiated dysplasia of a connecting tissue, complication, diagnostics, prophylaxis.