Ишемическая болезнь сердца с пограничными стенозами коронарных артерий. Клинические особенности. Соотношение паспортного и биологического возраста

Abstract

Introduction. Coronary artery disease (CAD) remains the main cause of disability and mortality among working-age people. A significant part of stable angina patients are patients with intermediate (40–70%) coronary artery stenosis. Aim. To study cardiovascular risk factors and make a comparative assessment of the clinical angiographic picture and vascular stiffness in stable angina patients with intermediate coronary artery stenosis, depending on the chronological age / biological age ratio, as well as to determine the level of long-term metabolites of nitric oxide (NO) – nitrites (NO2) . Materials and methods. 40 stable angina class I–III patients (36 men) aged 33–68 years with intermediate coronary artery stenosis were examined. Depending on the values of the chronological age / biological age coefficient (K), the patients were divided into two groups. The 1st group included patients with a biological age exceeding the passport age (K < 1.0 [0.53; 0.98]), the 2nd group included patients with a biological age equal or inferior to the chronological age (K ≥ 1.0 [1.1; 1.5], p < 0.01 ). Results. Stable angina patients with intermediate coronary artery stenosis represent a rather challenging group of people in terms of prognosis. Patients with increased biological age are characterized by an unfavorable course of the disease and a less favorable cardiometabolic profile compared to patients whose biological age corresponded to the chronological one. At the same time, the level of long-term metabolites of nitric oxide (NO) – nitrites (NO2) in plasma did not depend on the biological age of patients. Conclusion. The study of the biological age and level of long-term metabolites of nitric oxide (NO) – nitrites (NO2)in stable CAD patients with intermediate coronary artery stenosis is of great interest and requires further research.