Abstract
In 30 cases of mucoepidermoid carcinoma of the salivary glands, the expressions of proliferating cell nuclear antigen (PCNA) and c-erbB-2 oncogene products were investigated immunohistochemically. A statistically significant difference was found between solid regions (12.26±9.95) and tubular regions (0.77±2.01) on the basis of the PCNA index. Three types of c-erbB-2 antibodies (NCL-PC11, CB11, and CBE 1) showed different patterns of expression. C-erbB-2 (PC11) was expressed on the cell membranes of solid regions in 17 cases (57%) and tubular regions in 7 cases (23%). C-erbB-2 (CB11) was expressed in the cytoplasm of solid regions in 20 cases (67%) and tubular regions in 7 cases (23%). Moreover, cerbB-2 (CBE 1) was expressed in tubular regions in only 2 cases (7%). In the present study, PCNA index was not related to the overexpression of c-erbB-2 in mucoepidermoid carcinoma.
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