Вплив мультипробіотика «Симбітер® ацидофільний» концентрований на зміни в лімфоїдних органах щурів за умов тривалого зниження шлункової секреції соляної кислоти

Abstract

It was investigated the reaction of thymus and spleen in rats with 28 days decrease of gastric acid secretion on injection of multiprobiotic «Symbiter® acidophilic» concentrated (SYM). In rats, whom were injected only multyprobiotic SYM, relative thymus weight was not significantly changed in contrast to the relative cellness of this body, which grew significantly compared with the control. Hypoacid condition of gastric juice caused by the 28-day administration of rats by omeprazole (OM), led to a decrease of relative thymus mass while increasing relative content of lymphoid cells in this organ compared with the control group of animals. Putting away with OM multiprobiotic SYM caused growth of relative thymus weight compared with the group of rats who were administered OM, but the values of the control group animals and rats injected only SYM not reached. Relative cellness thymus in this group was in 2 times higher than in the control group, on 30% higher compared with rats with long hypoacid state and on 43% compared with rats, introduced by which only the SYM. Putting animals multiprobiotic SYM did not significantly alter the relative weight of the spleen and significantly increased relative cellness compared with the control. 28 daily inhibition of gastric secretion of hydrochloric acid by OM in rats led to moderate splenomegaly: increased mass index and relative content of spleen lymphoid cells in this body as compared to control animals. Concomitant administration of OM multiprobiotic SYM did not significantly alter the relative weight of the spleen, compared with a group of long hypoacidity and a group of rats that received only SYM, and leave increased this figure compared with the control. Relative spleen cellness in the same group of rats, which injected with OM and SYM, was on 40% more ten in groups of animals that received only OM, on 112% than in the control group and not significantly different from the group of rats which was injected only SYM. Thus, it was shown that long-term hypoacidity of gastric juice evoked cytomorphological changes in thymus and spleen. Injection of multiprobiotic «Symbiter® acidophilic» exert immunomodulatory action via activation of proliferative processes in observable lymphoid organs.