Особливості лікування жінок з внутрішньоматковою рідиною у постменопаузальний період

Abstract

The article presents data on the characteristics of the species composition of the microflora of the vagina of postmenopausal women with intrauterine fluid and developed an algorithm for treating this group of patients. The objective: is to study the species composition of the microflora of the vaginal contents in postmenopausal women with intrauterine fluid and based on these data on the development of a treatment algorithm. Materials and methods. The study was conducted for postmenopausal women with intrauterine fluid, who received the contents of the vagina with subsequent referral for microbiological examination. Then the patients were divided into groups to study the effectiveness of complex treatment. In the first group, two-stage treatment was carried out, including etiotropic treatment and the use of vaginal capsules with promestrin. In group II, only etiotropic treatment was performed. Results. As a result of microbiological analysis of the vaginal contents, the patients were divided into 3 groups depending on the microecology of the vagina: with atrophic colpitis 35 (52.2%), with bacterial vaginosis 26 (38.8%), with conditional normocenosis 6 (8.9%). Conducted treatment in groups and evaluation after 1–3–6 months. After 6 months of treatment, in groups I and II, a decrease in UPM by 85% and 47%, respectively, was found, and an increase in the contamination of the vaginal contents with lactobacilli by 87% and 43%, respectively (p<0.05), was also detected. Conclusion. In postmenopausal women with intrauterine fluid, massive microbial contamination of conditionally pathogenic and pathogenic vaginal microflora occurs. Through progressive estrogen deficiency, the unspecific resistance of the vaginal biotope is significantly reduced. The use of intravaginal capsules, which include promestrin, reduces the number of pathogenic and conditionally pathogenic microorganisms in the vagina and thereby reduces the likelihood of developing an ascending infection. Key words: postmenopausal period, intrauterine fluid, microbiological examination of the vagina, promestrin.