Изучение герпесвирусной инфекции в развитии острого оптического неврита неустановленной этиологии

Abstract

Purpose. Study of the etiological significance of herpesvirus infection (HVI) in patients with acute optic neuritis (ON) of unknown etiology using clinical and laboratory monitoring. Material and methods. Clinical and laboratory studies were carried out over 10 years and were based on the results of etiological monitoring of 81 patients (85 eyes) with acute ON in the period from 2008 to 2018. Results. During a comprehensive examination of 81 patients with acute ON, various infectious pathogens were diagnosed in 75 people (95 %). HVI dominated in 87 % of cases. In the total population of examined patients with acute ON associated with HVI, herpes simplex virus-1 was more common, Epstein – Barr virus and cytomegalovirus were less common. Active current HVI in the general group of patients was diagnosed in 58 patients (84 %). At the same time, the predominance (80 %) of reactivation of chronic infection was noted, and even less often (4 %), primary acute BBVI was diagnosed. The remaining 11 patients (16 %) had chronic persistent BBVI. Conclusion. Based on the complex of serological markers in the reactions of enzyme immunoassay of blood serum, it was found that the frequency of herpes virus infection is 87 %. The results of the performed clinical and laboratory studies are of great practical importance for the verification of the etiological diagnosis and the choice of adequate etiopathogenetic therapy in patients with acute ON associated with HVI. Keywords: acute optic neuritis, herpes virus infection, laboratory monitoring, serological markers.