Abstract
The influence of DDAVP on factor XI (F. XI), factor XII (F. XII), prekallikrein (PKK) and High Molecular Weight Kininogen (HMWK) in normal subjects was studied to clarify the hemostatic mechanism. A 12-16μg of DDAVP was injected intravenously to ten normal aubjects and aPTT, VIII: C, VIIIR: Ag, XI: C, XI: Ag, XII: C, XII: Ag, PKK: C, PKK: Ag, HMWK: C and HMWK: Ag were measured serially before and after the injection. And in vitro serial changes of aPTT, F. XI, F. XII and HMWK in mormal plasma after interaction with urokinase (UK) was studied. XI: C, XII: C and HMWK: C increased after DDAVP injection. But antigens of these did not increase. XII: C and HMWK: C after injection of DDAVP may be induced by fibrinolytic activity activated by the release of plasminogen activator. The increase of XI: C may be secondary activation due to the increase of XII: C and HMWK: C.
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