Abstract
Matrix metalloproteinase (MMP) activity in synovial fluid (SF) was studied with respect to age, sex, clinical findings, and MR images, to clarify factors related to MMP activity in SF of patients with closed lock of the temporomandibular joint (TMJ).Synovial fluid was obtained from 54 patients (58 joints) with TMJ closed lock. MMP-2, 3, and 9 activities in SF were detected by an MMP activity assay system with specific substrates for each enzyme.There were no significant correlations of MMP-2, 3, or 9 activity with age, sex, joint pain, or range of mouth opening. In addition, no significant correlations were found between MMP-2, 3, or 9 activity and the degree of disc deformity, or between MMP- 2 or 3 activity and the degree of bone changes. MMP-9 activity significantly increased in SF isolated from joints with severe bone changes (p<0.05).These results indicate that increased MMP- 9 activity is related to degenerative changes in the TMJ.
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