Abstract
Abstract. Introduction. Psoriatic disease is a genetically determined disease of a multifactorial nature that affects about 2% of the population. According to modern concepts of this pathology, there is a high level of comorbidities, especially those associated with damage to the cardiovascular system. The aim of the study is a comprehensive analysis of the features of epidemiological and clinical data linking psoriasis with cardiovascular risk factors and cardiovascular diseases. Material and Methods. A review and analysis of modern scientific data in the databases, such as eLibrary, PubMed/Medline, Web of Science, Google Scholar, and Cyberleninka for the period from 2000 to the present. Results and Discussion. Up-to-date information has been collected regarding comorbid cardiovascular pathology in psoriasis. We systematized the data related to the analysis of possible pathophysiological mechanisms that justify this relationship and analyzed the methods of cardiovascular risk stratification in patients with psoriasis. Conclusions. Various studies have shown that psoriasis is associated with a higher prevalence of cardiovascular diseases, including hypertension, diabetes mellitus, dyslipidemia, obesity, and metabolic syndrome. The relationship is discussed between psoriasis severity and the risk of developing cardiovascular diseases, as well as prognostic risks with mortality rates. The common pathogenetic mechanisms proposed include genetic factors, inflammatory pathways, adipokine secretion, insulin resistance, lipoprotein composition and function, angiogenesis, oxidative stress, and hypercoagulability.
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