Abstract
The challenge of diagnosis of inflammatory demyelinating diseases of the central nervous system is caused by their polymorphism and low specificity of symptoms. For their correct diagnosis it is necessary the presence of typical symptoms and absence of atypical features. The article presents clinical symptoms of some syndromes that may be a debut of multiple sclerosis, as well as other demyelinating disease (optic neuritis, partial transverse myelitis). The article presents a detailed description and diagnostic criteria of some syndromes with a high risk of transformation in multiple sclerosis: clinically isolated syndrome and radiologically isolated syndromes. A modern point of view on acute disseminated encephalomyelitis, neuromyelitis optica, Schilder’s disease and Balo’s concentric sclerosis and their differential diagnosis criteria with multiple sclerosis are presented.
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