Abstract
Isosorbide was administered to guinea pigs with experimentally induced endolymphatic hydrops, and endolymphatic space cross sections were measured with a microscope, video camera, and computer arrangement. The results were then compared with those in control guinea pigs which had not received isosorbide. Decrease in endolymphatic hydrops was most pronounced in the saccule and the basal turn of the cochlea, where hydrops was reduced by 25-30%. The decrease became progressively smaller towards the apex. The utricular space was virtually unaffected.
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