マイルド・ハイパーサーミアによる免疫能活性と抗腫瘍効果

Abstract

It is believed that hyperthermia will show anti-tumor effects at the temperature over 42.5 degrees. But we found that the mild hyperthermia as under 42.5 degrees still shows anti-tumor effects due to the immunological activity. We used C3H mice bearing SCC-VII tumor. These mice were heated at the temperature of 39-41 degrees by 1 hour in controlled water bath. After giving mild hyperthermia, white blood cells (WBC), lymphocyte cells (LyC), NK cell activity were increased compared with pre-heat condition. The delays of the SCC-VII tumor growth in C3H mice was observed after mild-hyperthermia. It shows that the immunological activity were increased as activated WBC, LyC and NK cells. Also anti-tumor effects were produced by mild hyperthermia. It is supposed that quantitative stimulation of femoral region by mild hyperthermia has induced the activation of hemopoietic organs in bone marrow of femoral region and this has activated immunological potency, mild hyperthermia seems to be a useful and effective auxiliary therapy which is not only effective for the treatment of malignant tumors but also for the treatment of diseases related to immunological activity (e. g. viral hepatitis type C, collagen diseases, AIDS, postoperative physical restraint, auxiliary therapy during thermotherapy, elimination of immunodeficiency, etc.).