Abstract
We present a case of IgA nephropathy associated with chronic tonsillitis. The patient had experienced continuous microhematuria, repeated proteinuria and visible hematuria every time when he had acute tonsillitis. Both proteinuria and microhematuria were worse after tonsillar provocation. Because of these results and history, this patient underwent with tonsillectomy. Proteinuria and microhematuria were disappeared two and three months after the operation, respectively. Levels of both serum IgA and urinary IL-6 were slightly higher than the normal levels before the operation. Serum IgA was decreased to the normal level one month after the operation. Urinary IL-6 was also decreased to normal two months after the operation. It is known that there is a correlation between the levels of urinary IL-6 and the pathological stage of mesangial proliferative glomerulonephritis (mesPGN), and that high urinary IL-6 activity indicates the histological progression of mesPGN including IgA nephropathy. The decrease of urinary IL-6 after the operation indicates the pathological improvement of the kidneys in this patient. Our observations suggest that the measurement of urinary IL-6 is helpful for monitoring not only the progression but also the improvement after tonsillectomy of pathological changes of the kidneys in IgA nephropathy.
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