頭頚部癌患者に対する動注化学療法および放射線療法による術前治療 カルボプラチンとシスプラチンの組織学的所見からみた効果の比較

Abstract

From the histological viewpoint, antitumor activity of carboplatin (CBDCA) was compared with that of cisplatin (CDDP), which had been studied previously, in the course of preoperative treatment combined with intraarterial chemotherapy and radiotherapy for head and neck cancers.The CBDCA group consisted of 13 previously untreated patients who received both the intraarterial chemotherapy with CBDCA (80mg/m2, on day 1 and 8) and peplomycin (PEP, 5mg/body/day, from day 1 to 5 and day 8 to 12) and 60Co-radiotherapy (2 Gy/day, total to 20 Gy) before surgery. The CDDP group consisted of 14 analogous patients who had received the same therapy except for intraarterial infusion of CDDP (20mg/m2, on days 1 and 8) in spite of CBDCA. The tumors in both groups were resected 7 to 10 days after the preoperative treatments and examined histologically in several portions.Therapeutic effects were judged according to Oboshi's histological classification in the resected materials. The effect of Grade II B or more, which meaned less than 1/4 living tumor cells, was judged as respondent, and that of Grade II A or less was as irrespondent. Nine out of 13 patients (69%) in CBDCA group and 11 out of 14 patients (79%) in CDDP group were judged as respondent. Though the difference of responsibility between the two groups was not statistically significant, it was impressed that CDDP group showed slightly greater response to the chemo-and radio-therapy.It was suggested from the above results that the CBDCA dosage should be increased within a limited dose with no severe adverse effects appearing.