Abstract
Culture-negative endocarditis remains a diagnostic and therapeutic challenge despite recent medical advances. Coxiella burnetii, the causative pathogen of Q-fever, weight with etiological structure of infective endocarditis. However, laboratory diagnosis is often underinformative, because the growth of C. burnetii in hemoculture is difficult and serological response can be paradoxical. The difficulties of diagnostic at Q-fever endocarditis motivate the consideration of the epidemiological characteristics and pathogenesis of Q-fever. These insights should help redefine preventive and therapeutic strategies against infective endocarditis.
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