Роль гиперпролактинемии в генезе преждевременного телархе и ее коррекция у девочек первых пяти лет жизни

Abstract

The family resource center MI «Dnipropetrovsk regional perinatal center with a hospital» DRC Isolated telarhe in girls of 1–5 years, often caused by increased levels of prolactin (PL), which plays an important role in the development of the female reproductive function (in general), and in mammohenezis (in particular). The aim of the study: to study the effectiveness of a drug Cyclodynon® on girls with an incomplete form of precocious puberty by the isosexual type – isolated telarhe on the base of increased levels of PL. Materials and methods. In the regional center of family planning on the basis of SI «Dnipropetrovsk regional perinatal center with a hospital» DRH survey was conducted in 30 girls aged from 1 to 5 years with premature isolated telarhe (PIT). Girls with isolated telarhe and a high level of PL were prescribed the drug, Cyclodynon® depending on the age and level of PL in serum at a dose from 1/8 of pill to 1 tablet (from 5 drops to 40 drops) in the morning on an empty stomach 1 time per day (guidelines of the Institute of health protection of children and adolescents of NAMS of Ukraine). Results. In the study to include 30 girls with isolated telarhe noted a steady increase of PL (up to 680 mIU/l for normal values 110-560 mIU/l) at relatively normal levels of gonadotropins and estradiol. Use of the drug of special extract of Vitex Agnus Castus – Cyclodynon® led to a gradual, within 3 months, reduce of prolactin levels to the normal range of 680 to 396 mIU/L. Reducing of prolactin levels correlated with regression of clinical signs of telarhe. No side effects or undesirable Cyclodynon® application within 3 months is not noted. Conclusion. A standardized herbal medicinal product Cyclodynon® with dopaminergic effect contributing to the normalization of PL for the treatment of girls with incomplete form of precocious puberty in isosexual type – isolated telarhe on the base of increased level of PL, is an effective and pathogenetically justified. This is confirmed by the results of clinical and hormonal reaserches. Key words: isolated telarhe, prolactin, Cyclodynon®.