Abstract
Purpose: To determine the diagnostic value of peroxynitrite and brain-derived neurotrophic factor in the genesis of perinatal lesions of the central nervous system. Materials and methods: 67 children were comprehensive survey during the first three months of life. All neonates were randomized and put into 4 groups, depending on the presence and severity of perinatal lesions of the central nervous system. The 1 group consisted of 15 infants with delayed manifestationt of perinatal lesions to the central nervous system. Тhe 2 group consisted of 19 children with cerebral ischemia (CI) I degree; in group 3 were 18 infants with CI II-III degree. The control group consisted of 15 healthy newborns. In the dynamics of observation in children was evaluated neurological status. The serum concentration rations of peroxynitrite by spectrophotometry and brain-derived neurotrophic factor using enzyme immunoassay system. Results: There were significant differences between production of peroxynitrite and brain-derived neurotrophic factor in children with disorders of the central nervous system as compared with control values. Summary: These changes underlie the formation of perinatal CNS, which allows us to consider them not only as markers of early diagnosis of perinatal brain lesions and its severity, but also as a criteria of adequacy of therapy.
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