Abstract
The majority of the known agents against human immunodeficiency virus (HIV) are targeted at the virus enzymes, protease and integrase, but do not prevent the HIV entry into host cells. Therefore, it is topical to seek for small polyanionic molecules as potential inhibitors of virus adsorption. Naturally occurring biologically active compounds, inositol-containing phospholipids taking part in the processes of cell regulation, may be promising lead compounds for drug design. In the present study, dimer analogs of inositol-containing phospholipids were synthesized using the H-phosphonate method and, on this basis, carboxymethyl and sulfo derivatives were obtained that are proposed as potential virus adsorption inhibitor.
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