Abstract
Aim: to describe the clinical pattern of antibiotic-associated diarrhea (AAD) and extraintestinal manifestations of antibiotic-associated syndrome (AAS) in children receiving different antibacterial therapy. Patients and Methods: this prospective clinical observational study was conducted in 2017–2019. The study included 231 children aged three months to 13 years admitted for community-acquired pneumonia and received antibacterial treatment. Clinical presentations of AAS (diarrhea, vomiting, dyspepsia, stomatitis) and extraintestinal presentations of AAS were evaluated in all children within a month after antibacterial treatment. In addition, clinical presentations of AAS were compared in children who received β-lactam antibiotics or macrolides. Results: AAS symptoms were diagnosed in 64.5% of children, while diarrhea was observed in 25%. In patients who received β-lactam antibiotics, the most common gastrointestinal (GI) signs were diarrhea, dyspepsia, loss of appetite, and constipation. In children who received ampicillin, the rate of GI signs was lower. In total, GI signs in AAS were less common in children who received macrolides compared to children who received β-lactam antibiotics. Minimal symptoms were associated with clarithromycin. Conclusion: AAS is one of the clinical manifestations of adverse effects of antibacterials on the human organism, including AAD and extraintestinal symptoms. The highest safety profile characterizes clarithromycin in terms of AAS. KEYWORDS: antibiotic-associated diarrhea, antibiotic-associated syndrome, adverse drug reactions, antibacterial treatment, macrolides, adverse effects, antibiotic-associated colitis. FOR CITATION: Golden L.B., Ploskireva A.A., Kanner E.V., Kanner I.D. Clinical pattern of antibiotic-associated syndrome in children receiving different antibacterial therapy. Russian Journal of Woman and Child Health. 2021;4(3):260–267 (in Russ.). DOI: 10.32364/2618- 8430-2021-4-3-260-267.
Highlights
Нормальный состав влагалищной микрофлоры чрезвычайно важен для восстановления и поддержания вагинального здоровья
Что данный штамм лактобактерий способствует повышению эффективности проводимой противомикробной терапии, а также предотвращает рецидивы Вульвовагинальный кандидоз (ВВК) и бактериальный вагиноз (БВ) [10, 15, 20]
This paper describes current approaches to the treatment for vulvovaginal atrophy in women of various ages with a special focus on the association between vaginal dryness and the reduction of both general and sexual quality of life
Summary
No authors have a financial or property interest in any material or method mentioned. РЕЗЮМЕ Цель исследования: изучить клинико-лабораторную эффективность использования комбинированного препарата (метронидазол 10 мг + клотримазол 20 мг (М+К) в 1 г геля) при лечении неспецифических вульвовагинитов смешанной этиологии у беременных в III триместре. Результаты исследования: после лечения отсутствие жалоб констатировали у 50 (94,3%) и 47 (90,4%) пациенток основной группы и группы сравнения соответственно (р=0,45). Локальный дискомфорт в момент введения препарата отмечали 3 (5,7%) и 4 (7,7%) пациентки основной группы и группы сравнения соответственно (р=0,68). На высокую удовлетворенность от использования препарата указали 47 (88,7%) беременных основной группы. Заключение: в исследовании получены данные, свидетельствующие о высокой эффективности терапии с использованием комбинированного препарата М+К в форме вагинального геля при лечении неспецифических вульвовагинитов смешанной этиологии у беременных в III триместре беременности. ДЛЯ ЦИТИРОВАНИЯ: Шапошникова Е.В., Базина М.И., Менцик М.М.
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