Abstract
The article presents the results of a study to determine the expression of estrogen and progesterone receptors in glandular polyps of endometrium in women during the postmenopause. The objective: to determine expression of estrogen and progesterone receptors in glandular endometrial polyps in postmenopausal women and levels of relevant hormones in the serum. Materials and methods. A prospective analysis of 39 cases of endometrial glandular polyps and fragments of healthy endometrium, in postmenopausal women, aged 45 to 65, was conducted. Levels of progesterone and estradiol in serum were measured. Immunohistochemically determined expression of estrogen and progesterone receptors in the stroma, glands of endometrial polyps and unchanged endometrium. Results. Our data suggest that polyps have stronger expression of estrogen and progesterone receptors than glands of unchanged endometrium. Expression of estrogen receptors was determined to be superior in the stroma of polyps compared with the stroma of the endometrium. Conclusion. Our results indicate that evaluation expression of steroid receptors may be a criterion for determining the malignant potential of polyps in postmenopausal women. Key words: immunohistochemistry, hysteroscopy, estrogen and progesterone receptor, postmenopausal, polyp, endometrium.
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