МЕТОД РЕСПИРАТОРНОЙ ПОДДЕРЖКИ ОСТРЫХ ХИМИЧЕСКИХ ПОРАЖЕНИЙ ЛЕГКИХ ПРОФЕССИОНАЛЬНОГО ГЕНЕЗА

Abstract

Introduction: Currently, the problem of chemical defeats at work continues to be relevant. According to the Federal Center for Hygiene and Epidemiology of Rospotrebnadzor, diseases (intoxication) caused by chemical factors exposure averaged 5.74–6.39% of occupational diseases per year all registered cases. As result of toxic substances inhalation, direct damage to lungs occurs with the further development of acute respiratory distress syndrome (ARDS). According to the national intensive care guide in the treatment of ARDS, the following main areas are distinguished - respiratory therapy and drug treatment. The latter includes infusion therapy, the use of glucocorticoids, surfactant preparations, narcotic analgesics and diuretics. Respiratory support consists in the use of mechanical ventilation (MV), and if the latter is not effective, extracorporeal membrane oxygenation (ECMO). Methods: literature data analyzes of acute chemical lung lesions treatment, as well as data on types, methods of liquid ventilation lung use. Results: It was found that the use of lungs both partial and total liquid ventilation using perfluorocarbon (PFC) compounds not only improved gas exchange in the lungs, but reduced the severity of the inflammatory response also. It was shown that the method of lung liquid ventilation (LVL) is promising. In turn, the increase in oxygenation we received, the increase in partial blood pressure during the alveolar phase of oedema, shows the advantage of liquid ventilation over existing ventilation regimes MV, thereby reflecting the potential of LAVL as a new method of respiratory support in acute lung lesions.