СИСТЕМА ПЕРЕКИСНОГО ОКИСЛЕНИЯ ЛИПИДОВ И АНТИОКСИДАНТНОЙ ЗАЩИТЫ У КЛИНИЧЕСКИ ЗДОРОВЫХ И БОЛЬНЫХ МАСТИТОМ КОРОВ

Abstract

Reactive oxygen species (ROS) and the nitric oxide system in most cases are involved in the body of sick animals as a means of combating microorganisms. Some scientists attribute the increase in cytokines to high levels of markers of oxidative stress and nitric oxide. The article presents the results of studying the LPO-AOD system of clinically healthy cows and cows with subclinical and clinically pronounced catarrhal mastitis. It was found that in cows with clinically pronounced catarrhal mastitis deeper disorders in the LPO-AOD system were revealed. This .was expressed by a further depletion of the antioxidant defense system, a decrease in the catalase activity by 24.3%, glutathione peroxidase activity – by 43.9%, vitamin A – by 36.6%, vitamin E – by 23.3% and vitamin C – by 45.3% in comparison with clinically healthy animals. There was a rise in the level of endogenous intoxication due to an increase in free oxygen species and lipid peroxidation products. Thus, in the blood of the animals, the 2.0 times increase in the content of malondialdehyde by was noticed, the number of medium molecular peptides increased – by 67.4%, index of endogenous intoxication – by 70.2%, nitric oxide – by 46.2%, in comparison with healthy animals. This proves excessive accumulation of products of lipid peroxidation and endogenous intoxication in the body of sick animals and increased inflammation in the mammary gland.