面不斉遷移金属錯体を基盤とする軸不斉化合物の立体選択的合成，および動的錯体への展開

Abstract

Axially chiral biaryls and N-aryl indoles are stereoselectively prepared by utilizing planar chiral transition metal complexes. Both enantiomers of axial biaryls and N-aryl indoles could be synthesized starting from an identical enantiomerically pure arene chromium complex. We applied this method to the synthesis of vancomycin A-B ring system and korupensamines. Kinetically controlled biaryl and N-aryl indole transition metal complexes with sp3 heteroatom at the side chain could be converted to thermodynamically stable complexes involving the inversion or transfer of planar chirality. These results indicate that transition metal fragment in planar chiral η6-transition metal complexes can be utilized as dynamic complexes with mobile chiral auxiliary.