만성대사성질환 개선에 대한 인삼과 홍삼의 임상연구 현황: 문헌고찰

Abstract

Background The pharmacological effects of Panax ginseng and red ginseng have been well known for a long time. However, there are no studies that comprehensively examine the effects of P. ginseng and red ginseng on chronic metabolic diseases. Therefore, this study comprehensively reviewed the effects of P. ginseng and red ginseng on chronic metabolic diseases by synthesizing clinical studies that were individually conducted for diabetes, obesity, hypertension, and hyperlipidemia. Methods and Results To evaluate the efficacy of P. ginseng or red ginseng for chronic metabolic diseases, literatures were collected using various databases from December 2020 to January 2021. For the selected studies, the quality of the studies was evaluated using the Risk of Bias tool, and the efficacy on chronic metabolic diseases was reviewed. For analysis, 9 studies using P. ginseng, 20 studies using red ginseng, and one study using P. ginseng and red ginseng were selected. Most of the selected studies were well designed and had low risk of bias. As a result of analyzing the effects on chronic metabolic diseases, it was confirmed that the biomarkers related to diabetes, hypertension, and hyperlipidemia were improved when taking P. ginseng or red ginseng. Conclusions Until now, the individual effects of P. ginseng or red ginseng on hyperglycemia, hypertension, and hyperlipidemia have been verified, but in the future, it is necessary to investigate comprehensive effects through clinical studies in high-risk subjects with chronic metabolic diseases.