馬杉腎炎の血清蛋白像, 尿蛋白像の電気泳動的研究

Abstract

In Masugi-nephritis, mild Masugi-nephritis and anaphylaxis of Masugi-nephritis, a study was made of urinary protein and serum protein on electrophoresis as well as on histological aspect.In serum protein of Masugi-nephritis, the following phenomena were observed : total protein showed an increase at the early stage and a remarkable decrease after the appearance of proteinuria ; albumin fraction showed a decrease after sensitization and a more remarkable decrease after the appearance of proteinuria ; globulin fraction showed an increase after sensitization and a more increase after the appearance of proteinuria ;α-globulin fraction showed the maximum before the appearance of proteinuria ;β-globulin showed the maximum after the appearance of proteinuria ;γ-globulin showed an increase after sensitization and a slight increase after the appearance of proteinuria.In mild Masugi-nephritis, each fraction showed slight changes with the same tendency as in Masugi-nephritis.In the control case of normal-duck-serum, there were observed a decrease in total protein and a decline of A/G, the latter being less in degree than that of Masugi-nephritis.An increase of globulin fraction chiefly depended upon that of γ-globulin fraction but not upon a slight increase of both α-globulin fraction and β-globulin fractions.In anaphylaxis of Masugi-nephritis, a decrease of γ-globulin fraction was found after an hour. The result after 84 hours revealed that total protein and albumin fraction had decreased but α-globulin and β-globulin fraction had increased.The above mentioned result showed some resemblance to the result obtained after the appearance of proteinuria in the case of Masugi-nephritis.In Masugi-nephritis, the urinary protein is consisted of fractions excluding fibringen in plasma protein, that is, albumin fraction, α-globulin fraction, β-globulin fraction and γ-globulin fraction. Albumin fraction, however, occupies the majority of the components.Proteinuria on the 9th day after sensitization, compared with that of the 14th day was generally low in albumin fraction and high in γ-globulin fraction.Histologically, pathological changes of typical glomerulitis were found in Masugi-nephritis, while in slight Masugi-nephritis they were milder than in the common cases. In anaphylaxis of Masugi-nephritis there was also found a similar glomerulitis.