Abstract
We present a digital dilution chip comprising a array of wells; the chip can be employed to change the dilution ratio as well as to initiate reactions among diluted samples by using the inter-well valve around the well. In previous dilution devices, streams comprising sample and dilution solutions were merged and separated by a branched microchannel. Therefore, the dilution ratio could not be changed until the structure of the branched microchannel was changed. The present device merges and splits the wells filled with sample or dilution solution by controlling inter-well valves around the wells. Thus, it is possible to change the dilution ratio by changing the sequence in which merging and splitting sequence of each well filled with sample or dilution solution. In experiments, we found that the chip could be used to change linear or exponential dilution ratios within an error of 16.7% and to initiate reactions among the samples within a reaction error of 17.7%.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Transactions of the Korean Society of Mechanical Engineers A
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
