Abstract
Passive arthritis induced by anticollagen antibody was a mild, transient disease from which the animals normally recovered and the rats that had recovered from passive arthritis were resistant to develop a second phase of arthritis following the subsequent challenge with type II collagen. Treatment with FK506 (FK) shortly before serum transfer suppressed passive arthritis completely. In contrast, treatment with cyclosporin A (CsA) didn't suppress this passive arthritis. Both FK-treated and CsA-treated, serum transferred rats failed to develop arthritis following a subsequent challenge with type II collagen. These results suggest that FK suppresses not only the activation or proliferation of T-cell but the other process of arthritis, without preventing the induction of immunologic unresponsiveness to type II collagen.
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