Abstract
The detection method of chiral discrimination ability of some macrocycles toward amino acid ester hydrochlorides using FAB mass spectrometry has been explained in this paper. The FABMS enantiomer labeled (EL) guest method, which was recently proposed by Sawada et al., was a useful and facile technique to detect chiral discrimination ability of new chiral hosts. A host (H) was complexed with 1 : 1 amino acid guest mixture of an (R)-enantiomer (GR+) and a deuterium labeled (S)-enantiomer (GS-dn+). The enantioselectivity of the host for the guest was quantitatively estimated from the relative peak intensity (I (H-GR)+/I (H-GS-dn)+=IRIS) values of the two host-guest complex ion peaks at a difference of m/z=n.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.